How accurate is an Amnisure test?

How accurate is an Amnisure test?

Amnisure has been extensively studied, and is a great tool to detect rupture of membranes. Multiple studies have shown sensitivity of 99%, with high positive and negative predictive values.

Can Amnisure be incorrect?

A small amount of blood admixture in the sample does not interfere with test results. A false negative result may occur when the sample is taken 12 or more hours after a presumed fetal membrane rupture has occurred. Amnisure is not affected by a hight dose hook effect.

What does Amnisure measure?

The Amnisure ROM test™ is approved by the FDA for the diagnosis of rupture of the fetal membranes (ROM). This test measures the concentration of placental alpha-microglobulin-1 (PAMG-1) in cervicovaginal fluid.

How accurate is Ferning test for amniotic fluid?

The diagnosis of rupture of the membranes by traditional methods of nitrazine paper determination and fern crystallization has been reported to be 93-98% accurate. Although the presence of contaminants in amniotic fluid has been reported to reduce this accuracy, the literature is conflicting concerning these effects.

How accurate is actim prom?

Results: In this study, the sensitivity and the specificity of IGFBP-1 (Actim PROM test) in diagnosing PROM were 89.3% and 82.7%, respectively, as compared with 84% sensitivity and 78.7% specificity for Ferning test, and 86.7% sensitivity and 81.3% specificity for Nitrazine test.

Is Amnisure affected by blood?

In fact, the specificity of AmniSure in the presence of blood (91.5%, this study) is greater than that of the IGFBP-1 test without vaginal bleeding (87.8%, this study) (Figure 4).

Which finding is most accurate for confirming rupture of the amniotic sac?

Pooling of fluid is by far the most accurate for diagnosis of ROM. If all fluid has leaked out as in early PROM, an ultrasonographic examination may then show absence of or very low amounts of amniotic fluid in the uterine cavity.

How accurate is a Nitrazine test?

The accuracy of the applied tests was 92.1%, 93.6%, 82.8% and 72.8% respectively for SPONT, Nitrazine, Fern and Pooling tests. There wasn’t significant difference between accuracy of SPONT and standard clinical assessment (92.1% vs. 89.3%).

What does a positive AmniSure test mean?

The Amnisure ROM™ test is approved for the diagnosis of rupture of membranes (ROM). Yet, a fraction of patients with a positive test have intact membranes by sterile speculum examination.

How is Srom diagnosed?

ROM is diagnosed by speculum vaginal examination of the cervix and vaginal cavity. Pooling of fluid in the vagina or leakage of fluid from the cervix, ferning of the dried fluid under microscopic examination, and alkalinity of the fluid as determined by Nitrazine paper confirm the diagnosis.

How do you perform an AmniSure test?


  1. Collect sample of vaginal discharge with sterile collection swab (no speculum required).
  2. Rinse specimen swab in solvent vial. Discard swab.
  3. Insert amniotic fluid test strip into vial and remove if 2 lines are visible, or at 10 minutes sharp.
  4. Results are observed and recorded.

How do you perform an Amnisure test?