Is ar a transcription factor?

Is ar a transcription factor?

UniProtKB/Swiss-Prot Summary for AR Gene Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription activation is also down-regulated by NR0B2.

What is AR signaling?

The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC), which arises after failure of androgen deprivation therapy (ADT).

What is AR ligand?

AR ligands can either be classified based on their structure (steroidal or nonsteroidal) or based on their ability to activate or inhibit transcription (agonists or antagonists). Inhibitors that target alternative functional domains (N-terminal domain, DNA-binding domain) of the protein are still under development.

Is AR positive?

Describes cells that have a protein that binds to androgens (male hormones). Cancer cells that are androgen receptor positive may need androgens to grow. These cells may stop growing or die when they are treated with substances that block the binding and actions of androgen hormones. Also called AR positive.

What does the AR gene do?

The AR gene provides instructions for making a protein called an androgen receptor. Androgens are hormones (such as testosterone) that are important for normal male sexual development before birth and during puberty. Androgen receptors allow the body to respond appropriately to these hormones.

Where is the AR gene?

The gene encoding androgen receptor (AR), alternatively known as the dihydrotestosterone receptor, is located on the X chromosome.

Is pc3 AR positive?

The majority of human prostate cancer cell lines, including the two “classical” cell lines DU-145 and PC-3, are reported to be androgen receptor (AR)-negative.

What is AR expression?

Background. The androgen receptor (AR) is an emerging prognostic marker and therapeutic target in breast cancer. AR is expressed in 60–80% of breast cancers, with higher prevalence among estrogen receptor-positive (ER+) tumors.

What is androgen therapy used for?

Hormone therapy is also called androgen suppression therapy. The goal is to reduce levels of male hormones, called androgens, in the body, or to stop them from fueling prostate cancer cells. Androgens stimulate prostate cancer cells to grow. The main androgens in the body are testosterone and dihydrotestosterone (DHT).

What is an AR mutation?

Androgen receptor (AR) gene mutations are the most frequent cause of 46, XY disorders of sex development and associated with a variety of phenotypes, ranging from phenotypic women (complete androgen insensitivity syndrome (CAIS)) to milder degrees of undervirilization (partial form or PAIS) or men with only infertility …

What does Gorilla mode AR do?

It enhances mental focus and alertness by increasing memory related functions. Burns Transports Fatty Acids to support your Cardiovascular Energy Levels. It can increase oxygen supply to the muscles.