What is CIA mouse model?

The collagen-induced arthritis (CIA) mouse model is the most commonly studied autoimmune model of rheumatoid arthritis. Autoimmune arthritis is induced in this model by immunization with an emulsion of complete Freund’s adjuvant and type II collagen (CII).

How does collagen induce arthritis?

Collagen-antibody-induced arthritis (CAIA) is an inflammation that is dependent on Fc receptor and complement, involving the infiltration of both neutrophils and macrophages [15–18]. The antibody response to CII is predominantly directed towards the conformational triple-helical structures.

How do you induce arthritis in mice?

D. Complete Freund’s Adjuvant (CFA), consisting of high-quality M. tuberculosis, is essential to induce severe arthritis in mice because it induces a strong immune response. Unlike rats, mice will not develop arthritis by immunizing with type II collagen emulsified with Incomplete Freund’s Adjuvant (IFA).

How do you induce arthritis in rats?

In practice, mineral oil, squalane, and liquid paraffin are equally effective for inducing arthritis in a variety of AIA-susceptible rat strains. Various strains of heat killed mycobacteria, such as MT and isolated PGs and MDP can be used as antigens for inducing AIA.

What is adjuvant induced arthritis?

Definition. Adjuvant-induced arthritis is a model of chronic immune-mediated joint inflammation that is induced by injection, usually sub– or intradermally, of a suspension of heat killed Mycobacterium tuberculosis ( Mycobacterium Species) in oil ( Freund’s complete adjuvant or FCA).

Do mice get arthritis?

Rheumatoid arthritis (RA) remains a uniquely human disease. Dozens of preclinical arthritis models have been developed in a variety of species (e.g. mouse, rat, rabbit and monkey) that involve spontaneous or induced synovial inflammation.

Can mice get arthritis?

Can rats get arthritis?

For example, Lewis (LEW/N) rats develop severe chronic disease, whereas histocompatible Fischer (F344/N) rats develop mild arthritis that rapidly subsides.

What is Freund’s complete adjuvant?

2.2 Complete freund’s adjuvant (CFA) CFA is a suspension of dessicated mycobacterium in paraffin oil and mannide monooleate that induces inflammation, tissue necrosis, and ulceration. It can be used subcutaneously in the paw, or intraperitonealy in mice and rats. A period of 24 h is required for onset after injection.

Is this a mouse or a rat?

A mature mouse can be distinguished from a young rat by its larger ears and longer tail compared to its body length than the rat. A young rat also has distinctly larger feet and head compared to the body than a mouse. Mice are usually light grey or brown in colour with a lighter shade on their bellies.

What animals is RA?

Sometimes Ra is shown in animal form; most commonly, Ra is shown as a hawk, but sometimes also a beetle, lion, ram, or snake, as all of these were considered powerful animals in ancient Egypt. In iconography, Egyptians sometimes painted Ra as simply a large solar disk between two large falcon wings.

Can rats have glucosamine?

Results: OA rats receiving glucosamine showed a significantly lower degree of cartilage degeneration than the rats receiving placebo. Glucosamine treatment also suppressed synovitis.