What is cisplatin based combination chemotherapy?

What is cisplatin based combination chemotherapy?

Abstract. Purpose: Cisplatin-based chemotherapy is standard first-line treatment for metastatic urothelial carcinoma. However, cisplatin is frequently avoided in elderly patients due to concerns regarding toxicities. We analyzed the efficacy, and tolerability, of cisplatin-based chemotherapy in elderly patients.

What is known about combination chemotherapy regimens?

Combination chemotherapy is the use of more than one medication at a time to treat cancer. Since chemotherapy drugs affect cancer cells at different points in the cell cycle, using a combination of drugs increases the chance that all of the cancer cells will be eliminated.

Why combination chemotherapy is given?

The rationale for combination therapy is to use drugs that work by different mechanisms, thereby decreasing the likelihood that resistant cancer cells will develop. When drugs with different effects are combined, each drug can be used at its optimal dose, without intolerable side effects.

Which cancers are treated with cisplatin?

Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.

What are the side-effects of combination therapy?

The most common side-effects of combined chemohormonal therapy were gastro-intestinal (nausea, vomiting, rarely diarrhoea) in 43 patients (57.3%), followed by alopecia in 23 patients (30.6%), myelosuppression in 12 patients (16%), extravasation and thrombophlebitis in 7 patients (9.3%), and mucositis and oral erythema …

Why is combination therapy better than monotherapy?

On the other hand, several factors argue in favour of combination therapy: a broader antibiotic spectrum, in vitro data showing synergy of antibiotic combinations2, lower efficacy of colistin monotherapy compared to betalactam monotherapy62, lower risk of resistance development (e.g. against colistin)1, lower doses and …

How long can you stay on cisplatin?

Your course of chemotherapy You have chemotherapy as a course of several sessions (or cycles) of treatment over a few months. Each cycle of cisplatin usually takes 21 days (3 weeks).