What is peptide T (DAPTA)?

Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells. Peptide T has several positive effects related to HIV disease and Neuro-AIDS.

What is the standard temperature of Peptide T?

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Peptide T is an HIV entry inhibitor discovered in 1986 by Candace Pert, a US neuroimmunologist.

What are the effects of Peptide T on HIV disease?

Peptide T has several positive effects related to HIV disease and Neuro-AIDS. A FDG-PET neuro-imaging study in an individual with AIDS dementia who completed a 12-wk treatment with intranasal DAPTA, showed remission in 34 out of 35 brain regions after treatment.

What is peptide T in Dallas Buyers Club?

In the 2013 biographical film Dallas Buyers Club, protagonist Ron Woodroof ( Matthew McConaughey) promotes the use of injected peptide T as a treatment for HIV/AIDS and Alzheimer’s disease and sues the FDA over their efforts to limit his ability to use peptide T, as it was an unapproved medicine.