What is the cluster of differentiation for B cells?

Clusters of Differentiation (CD) proteins are a group of cell surface markers that can be used to identify different stages of B cell development or activation, including progenitor B cells, pro-B cells, pre-B cells, immature B cells, transitional 1 B cells, transitional 2 B cells, marginal zone B cells, na?

Which cells have the cluster of differentiation 4 CD4?

Cluster of differentiation 4 is a glycoprotein found on the surface of cells such as T cells, monocytes, macrophages, and dendritic cells.

What happens during lymphocyte activation?

Lymphocyte activation occurs when lymphocytes (B cells or T cells) are triggered through antigen-specific receptors on their cell surface. This causes the cells to proliferate and differentiate into specialized effector lymphocytes.

What is cluster of differentiation in immunology?

The cluster of differentiation (CD) designation refers to proteins found on the surface of cells. Each unique surface molecule is assigned a different number, which allows cell phenotypes to be identified. Surface expression of a particular CD molecule is useful for the characterization of cell phenotypes.

Why is it called cluster of differentiation?

These cell surface molecules of leukocytes are routinely detected with anti-leukocyte monoclonal antibodies. Clusters of antigens on the surface of leukocytes can be designated by their reactions with monoclonal antibodies. This designation of the antigens is called clusters of differentiation (CDs).

How are T cells differentiated from other lymphocytes?

All T cells contain the CD3 surface marker, which can be used to differentiate T cells from other lymphocytes. T cells can be further segregated into two specific classes: T-helper cells and T-suppressor cells. T-helper cells are distinguished by having CD4 surface markers, while T-suppressor cells have CD8 surface markers.

Which lymphocytes have the highest CD45 expression?

Among the lymphocyte subsets, the expression of CD45 was the highest (725,368±42,763) on natural killer T (NKT) cells, 674,030±48,187 on cytotoxic/suppressor T cells, 588,750±48,090 on natural killer (NK) cells, 580,211±29,168 on helper T (Th) cells, and 499,436±21,737 on B cells.

What are the effects of lymphoid cell differentiation blockage?

In ALL, blockade of lymphoid cell differentiation leads to persistent proliferation, defective cell death, and accumulation of leukemic lymphoblasts in tissues.

What is CD in hematopoietic differentiation?

Antigenic markers of hematopoietic differentiation are called CDs (for clusters of differentiation ). There are more than 300 CDs, but the ones used in hematopoietic malignancies are relatively limited. Still more limited is the number of CDs that can be tested in FNAs, because of the limitation of the material.