Which is the pathogen of filariasis?
Causative Agents. The causative agents of lymphatic filariasis (LF) include the mosquito-borne filarial nematodes Wuchereria bancrofti, Brugia malayi, B. timori An estimated 90% of LF cases are caused by W. bancrofti (Bancroftian filariasis).
What is the pathophysiology of filariasis?
Filariasis infection occurs when a larva carrying mosquito bites an individual, introducing these larvae into the skin. The larvae then enters the patient’s blood through the skin wound and spread to the different sites such as lymphatic vessels, subcutaneous tissues or the serous cavities.
When filaria block lymphatic vessels they cause the disease called?
Lymphedema occurs when the lymph vessels are not able to adequately drain lymph fluid, usually from an arm or leg. The most common causes of lymphedema include: Cancer. If cancer cells block lymph vessels, lymphedema may result.
What kind of disease is elephantiasis?
Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. It is caused by infection with parasites classified as nematodes (roundworms) of the family Filariodidea that are transmitted through the bites of infected mosquitos.
What is the vector of filariasis?
Lymphatic filariasis is a vector-borne disease, being transmitted by mosquitoes (e.g. Culex, Anopheles and Aedes mosquitoes).
How does filariasis cause lymphatic obstruction?
Lymphatic filariasis is caused by three different species of worms known as Brugia malayi, Brugia timori and Wuchereria bancrofti. These worms cause damage and inflammation to the lymphatic system. The larval form of the worms is introduced into the human body through the bite of infected mosquitoes.
What is the pathogenesis of elephantiasis?
Elephantiasis occurs in the chronic stage of lymphatic filariasis due to the obstruction of lymphatic vessels by filariae. After invasion into lymph vessels, third stage larvae grow to maturity in the lymphatic system, mainly in and around the genitourinary system.
Is filariasis vector-borne disease?
Lymphatic filariasis is a vector-borne disease, being transmitted by mosquitoes (e.g. Culex, Anopheles and Aedes mosquitoes). Infected individuals may be asymptomatic, with no external sign of infection.
What is the mode of transmission of filariasis?
The disease spreads from person to person by mosquito bites. When a mosquito bites a person who has lymphatic filariasis, microscopic worms circulating in the person’s blood enter and infect the mosquito.
What is Brugia timori and how is it transmitted?
Wuchereria bancrofti (transmitted by the Mansonia and Anopheles vectors), Brugia malayi and Brugia timori (both transmitted by Culex quinquefasciatus) are the filarial species in this region.
What is the pathogenesis of Brugia malayi?
Pathogenesis of Brugia malayi. Humans are the definitive host and mosquitoes are the intermediate hosts of Brugia spp. Infected human are the main sources and reservoir of infection. Man to Man transmission occurs by the bite of Anapheles and Mansonia. The life cycle of filarial parasites involves four larval stages and an adult stage.
What is the intermediate host of Brugia spp?
Humans are the definitive host and mosquitoes are the intermediate hosts of Brugia spp. Infected human are the main sources and reservoir of infection. Man to Man transmission occurs by the bite of Anapheles and Mansonia. The life cycle of filarial parasites involves four larval stages and an adult stage.
What is the history of Brugia?
Brug in 1927 describe for the first time about new type of microfilaria in blood of natives in Sumatra. From where the genus acquired its name, Brugia. The adult B.malayi worm of was described by Rao and Maplestone in India (1940).