# How do you calculate stereogenic centers?

## How do you calculate stereogenic centers?

There are four things to watch for when identifying stereocenters:

1. Wedges and dashes do not necessarily mean it is a stereocenter.
2. Don’t just look at the atoms directly attached to the stereocenter.
3. Watch out for hydrogen atoms that are not shown.
4. Double or triple bonds cannot be stereocenters.

Which compound contains a stereogenic Center?

Compounds with Several Stereogenic Centers

Ephedrine from Ma Huang: m.p. 35 – 40 º C, [α]D = –41º, moderate water solubility [this isomer may be referred to as (–)-ephedrine]
Pseudoephedrine from Ma Huang: m.p. 119 º C, [α]D = +52º, relatively insoluble in water [this isomer may be referred to as (+)-pseudoephedrine]

### What would be the specific rotation of a sample that contains 39% of (-) paroxetine and 61% of its enantiomer?

(e) What would be the specific rotation of a sample that contains 39% of (-) – Paroxetine and 61% of its enantiomer? Observed specific rotation = (0.39) x (-24.3) + (0.61) x (24.3) = +5.346 Page 9 9 20. Ampicillin has been one of the most widely prescribed antibiotics.

Would the following compound have an enantiomer?

Would the following compound have an enantiomer. Explanation: Yes, this compound has enantiomer because of the steric bulk of the phenyl groups, the molecule would be held in place.

#### What’s a Stereogenic Center?

A stereocenter or stereogenic center is an atom bearing groups such that an interchanging of any two groups leads to a stereoisomer. By definition, molecules that are stereoisomers of each other represent the same structural isomer.

How do you calculate chiral carbons?

The key to finding chiral carbons is to look for carbons that are attached to four different substituents. We can immediately eliminate any carbons that are involved in double bonds, or that have two hydrogens attached. Given this, we find that there are three chiral carbons.

## What is stereogenic center with example?

Isomerism of this type is possible when a molecule has more than one stereogenic centre. A simple example is the 2,3-dichloropentane molecule shown below, in which C(2) and C(3) are stereogenic carbons. The molecule has two stereogenic centres, and four stereoisomers are possible.

What is the formula for specific rotation?

The CRC Handbook of Chemistry and Physics defines specific rotation as: For an optically active substance, defined by [α]θλ = α/γl, where α is the angle through which plane polarized light is rotated by a solution of mass concentration γ and path length l.

### Does Oh have higher priority than CH2OH?

anti-clockwise = (S) For example, in (+)-glyceraldehyde the order of priority of the groups is OH > CHO > CH2OH > H and the configuration is (R).

Which statement is correct for enantiomers?

We have to know that enantiomers have different configurations at the stereogenic centre because they are mirror images to each other. Therefore, the option (C) is correct. Enantiomers are not superimposable.