How is TB meningitis diagnosed in CSF?

Definitive diagnosis of tuberculous meningitis can be made by demonstration of mycobacteria in cerebrospinal fluid (CSF), by direct staining or culture. However, these tests are time consuming and seldom positive.

What is the color of CSF in TB meningitis?

Conclusions: Clear CSF with colorless appearance, lymphocyte pleocytosis, high protein level, and low CSF glucose as well as blood glucose ratio remain typical CSF characteristics of TBM patients found at the Department of Neurosurgery, Dr.

WHO TB meningitis treatment guidelines?

Antimicrobials. Current WHO guidelines for TBM are based on those developed to treat PTB and suggest treatment with 2 months of rifampicin (RMP), isoniazid (INH), pyrazinamide (PZE) and ethambutol (ETB) followed by up to 10 months of RMP and INH for all patients [7].

Why is CSF protein high in bacterial meningitis?

During bacterial infection, the protein level in the CSF goes up, due to the increased numbers of replicating bacteria and body cells fighting the infection, with both of them having a high concentration of protein. High levels of lactate in CSF indicate a higher likelihood of bacterial meningitis.

What is Ada CSF?

To study the cerebrospinal fluid (CSF) adenosine deaminase (ADA) levels in tuberculous meningitis (TBM) and non-TBM -viral meningitis cases and to determine its diagnostic significance as a biochemical marker of TBM infection.

Why is CSF glucose low in meningitis?

The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection. However, the possibility that the bacteria itself could manipulate glucose concentrations in the brain had not been explored before now.

Why CSF test is done?

Why the Test is Performed This test is done to measure pressures within the CSF and to collect a sample of the fluid for further testing. CSF analysis can be used to diagnose certain neurologic disorders. These may include infections (such as meningitis) and brain or spinal cord damage.

Why CSF glucose is low in bacterial meningitis?