What drugs are GnRH agonists?

GnRH agonists (sold under the brand names Lupron, Zoladex, Trelstar, Viadur, Vantas, Eligard and Synarel – see Table below) are drugs that lower male hormones, which has the effect of shrinking prostate tumors or slowing the growth of prostate cancer. This therapy is known as Androgen Deprivation Therapy or ADT.

What are some examples of GnRH agonists?

The commercial names and year of approval in the United States of the currently available forms of GnRH agonists and antagonists are: leuprolide, also called leuprorelin (Lupron: 1985), goserelin (Zoladex: 1989), histrelin (Supprelin, Vantas: 1991 and 2004), triptorelin (Trelstar: 2000), and degarelix (Firmagon: 2008).

What are GnRH agonists used for?

Gonadotropin releasing hormone agonists (GnRH) are a type of medication that suppresses ovulation by stopping the production of estrogen and progesterone. In order for this axis to function properly and result in ovulation, GnRH has to be released in a pulsatile fashion.

What drug belongs to GnRH antagonists?

Gonadotropin-releasing Hormone Antagonists

Drug	Drug Description
Cetrorelix	A synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy.
Degarelix	A GnRH receptor antagonist used in the management of advanced prostate cancer.

What are hormone agonists?

ChEBI ID. CHEBI:51060. Definition. A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.

Is Lupron a GnRH agonist or antagonist?

Leuprolide injection (Lupron Depot) is also used with other medication to treat anemia (a lower than normal number of red blood cells) caused by uterine fibroids (noncancerous growths in the uterus). Leuprolide injection is in a class of medications called gonadotropin-releasing hormone (GnRH) agonists.

Is Orilissa a GnRH agonist?

Elagolix, sold under the brand name Orilissa, is a gonadotropin-releasing hormone antagonist (GnRH antagonist) medication which is used in the treatment of pain associated with endometriosis in women. It is also under development for the treatment of uterine fibroids and heavy menstrual bleeding in women.

What does a hormone agonist do?

A substance that keeps the testicles and ovaries from making sex hormones by blocking other hormones that are needed to make them. In men, gonadotropin-releasing hormone agonists cause the testicles to stop making testosterone. In women, they cause the ovaries to stop making estrogen and progesterone.

What drugs are LHRH antagonists?

LHRH agonists

Leuprolide (Lupron, Eligard)
Goserelin (Zoladex)
Triptorelin (Trelstar)
Leuprolide mesylate (Camcevi)

How do GnRH agonists work for fibroids?

GnRH agonists work by ‘switching off’ the ovaries, meaning that they reduce the production of oestrogen and progesterone (as the ovaries do not receive gonadotropin stimulation), resulting in low gonadotropin levels.

What is a gonadotropin releasing hormone (GnRH) agonist?

The gonadotropin releasing hormone (GnRH) agonists and antagonists are short peptide analogues of GnRH that cause a profound inhibition of estrogen and androgen synthesis and are used predominantly as androgen deprivation therapy of advanced prostate cancer.

What are the clinical applications of GnRH analogs?

GnRH analogues have achieved widespread clinical use for the control of reproduction in animals. Over 2000 analogues of GnRH have been developed and tested over the last 30 years.

What is the role of GnRH agonists in precocious puberty?

Since 1981, GnRH agonist administration has been the treatment of choice for central precocious puberty. Continuous administration of the agonist, instead of permanently stimulating gonadotropin secretion, deeply suppresses LH and FSH levels and induces a marked inhibition of gonadal activity and regression of clinical symptoms.

What are the essential features of GnRH antagonists?

The essential features required of antagonists are a high affinity for the GnRH receptor (binding but without activation), low histaminergic properties and resistance to enzymatic degradation ( Karten and Rivier, 1986 ). Evaluation of the inhibitory actions of the antagonists can be achieved using similar systems to the agonists.