What is CLEC12A?

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene. This gene encodes a member of the C-type lectin /C-type lectin-like domain (CTL/CTLD) superfamily.

Does clec12a-cd33 car have specific anti-tumor activity against CD33 cells?

In vitro assays indicated that the CLEC12A-CD33 CAR had specific anti-tumor activity against cell lines positive for CD33 or CLEC12A, as well as primary leukemia samples from AML patients.

Does CLEC12A contribute to the pathophysiology of rheumatoid arthritis?

Since CLEC12A encodes for the myeloid inhibitory C-type lectin-like receptor that modulates cytokine synthesis, this receptor may contribute to the pathogenesis of RA.

Is CLEC12A a potential target for immunotherapy in cytopenias?

Lack of expression on the normal hematopoietic stem and progenitor cells, in contrast to CD123 and CD33, might result in less toxicity regarding cytopenias, making CLEC12A an interesting target for innovating immunotherapies, including monoclonal and bispecific antibodies, antibody-drug conjugates and CAR-T cells therapy. 1. Introduction