What is PEGASUS trial?

What is PEGASUS trial?

PEGASUS – TIMI 54 was a randomized, double-blind, placebo-controlled trial to assess the prevention of thrombotic events with ticagrelor on a background of aspirin therapy in patients with history of myocardial infarction.

What is Pegasys injection?

PEGASYS® (peginterferon alfa-2a) is a prescription medication that is: used with other hepatitis C medicines to treat adults with chronic (lasting a long time) hepatitis C and certain types of liver problems.

Is Pegasys used for polycythemia vera?

Peginterferon alfa-2a (Pegasys®) is an Immunotherapy Regimen for Polycythemia Vera.

What is Pegasus disease?

Pemphigus is a rare skin disorder characterized by blistering of your skin and mucous membranes. The most common type is pemphigus vulgaris, which involves painful sores and blisters on your skin and in your mouth. Pemphigus foliaceus. Close.

What APL 2?

APL-2 is a synthetic cyclic peptide conjugated to a polyethylene glycol (PEG) polymer that binds specifically to C3 and C3b, effectively blocking all three pathways of complement activation (classical, lectin, and alternative).

What are the side effects of ticagrelor?

Side Effects

  • Back pain.
  • chest pain, tightness, or discomfort.
  • coughing up blood.
  • difficult or trouble breathing.
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.
  • fast, slow, or irregular heartbeat.
  • increased menstrual flow or vaginal bleeding.

What is TIMI major bleeding?

TIMI major bleeding is defined as patients with intracranial hemorrhage or a ≥5 g/dl decrease in hemoglobin concentration or a ≥15 % absolute decrease in hematocrit.

How does Pegasys interferon work?

Combining peginterferon alfa-2a or alfa-2b with ribavirin produces better activity against HCV than either drug alone. Interferon works by binding to specific receptors on the cell surface that initiate a complex cascade of protein-protein interactions leading to rapid activation of gene transcription.

What kind of doctor treats pemphigus vulgaris?

How is pemphigus vulgaris diagnosed? You may need to see a dermatologist to diagnose and treat this condition.

What is the clinical trial for Pegasys 180μg?

Post-marketing Clinical Trial of Pegasys® 180μg for Subcutaneous Injection in Patients With Chronic Hepatitis C. General Clinical Study in Interferon (IFN)-Treated and IFN-untreated Chronic Hepatitis C Patients, Except for Those Infected With High Viral Load of Genotype 1b

Can Pegasys (ifn-alpha2a) help to control CML?

The goal of this clinical research study is to see if Pegasys (IFN-alpha2a) can help to control the disease in patients with ET, PV, AMM/MF, and Ph-negative CML. The safety of this treatment will also be studied. IFN-alpha2a has been used for the treatment of a variety of disorders (such as hepatitis C).

What did we learn from the Pegasus-Timi 54 trial?

Furthermore, the PEGASUS-TIMI 54 trial evaluated two doses of ticagrelor therapy: 90 mg twice daily, which has been studied previously in acute coronary syndromes, 11 and 60 mg twice daily, which was selected to provide slightly less, but still consistent, platelet inhibition.

How is ticagrelor administered in a randomized controlled trial?

Eligible patients were randomly assigned, in a 1:1:1 ratio within each study site, to receive ticagrelor orally at a dose of 90 mg twice daily, ticagrelor orally at a dose of 60 mg twice daily, or placebo. Randomization was performed with the use of a central computerized telephone or Web-based system, and assignment was double-blinded.