Where is thalidomide absorbed?
Thalidomide is minimally metabolised by the liver, but is spontaneously hydrolysed into numerous renally excreted products.
What is thalidomide used for?
In the 1950s and 1960s, thalidomide was used to treat morning sickness during pregnancy. But it was found to cause disabilities in the babies born to those taking the drug. Now, decades later, thalidomide (Thalomid) is being used to treat a skin condition and cancer.
How is thalidomide metabolized?
Thalidomide undergoes biotransformation by non-enzymatic hydrolysis and enzyme-mediated hydroxylation to form a multitude of metabolites.
What is the group of thalidomide?
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione is a dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. It is a member of piperidones and a member of phthalimides.
What class of drug is thalidomide?
Thalidomide is in a class of medications called immunomodulatory agents. It treats multiple myeloma by strengthening the immune system to fight cancer cells.
Is thalidomide a chemotherapy drug?
Thalidomide is a type of targeted cancer drug. It is also known as Thalidomide Celgene. It is a treatment for myeloma and myelofibrosis.
What is the classification of thalidomide?
What was the thalidomide tragedy?
The thalidomide tragedy occurred in the 1950s, a time when the standards of regulation in the pharmaceutical industry were not nearly as rigorous as they are today. Thalidomide was first marketed in Germany during the mid-1950s as a drug to aid with sleeping problems and insomnia.
What is the pharmacokinetics of thalidomide in HIV patients?
Thalidomide has increasing clinical benefits, including the healing of aphthous ulcers in patients with HIV. Unfortunately, pharmacological information addressing the pharmacokinetics (PK) of this compound in HIV patients is limited. Concern exists as to whether thalidomide may alter its own metabol …
What is the role of thalidomide in multiple myeloma treatment?
Hideshima T, Chauhan D, Shima Y, Raje N, Davies FE, Tai YT, Treon SP, Lin B, Schlossman RL, Richardson P, Muller G, Stirling DI, Anderson KC. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood.
How safe is thalidomide?
Thalidomide became one of the world’s largest selling drugs, and was marketed heavily and advertised as completely safe (Vargesson, 2009; Fig. Fig.1B)1B) right up until it was eventually banned in November, 1961.