Who should not take zidovudine?

Who should not take zidovudine?

You should not use zidovudine if you are allergic to it. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you’ve taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Why zidovudine and stavudine should not be used in combination?

The combination of stavudine (d4T) and didanosine (ddI), initially thought to be contraindicated because of the overlapping toxicity profiles of the 2 drugs, was found not only to be safe but to provide more potent antiviral activity than either drug administered alone [1, 2].

What are the side effects of lamivudine and zidovudine?

Lamivudine and zidovudine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • diarrhea.
  • heartburn.
  • difficulty falling asleep or staying asleep.
  • depression.
  • stuffy nose.
  • cough.
  • joint pain.

What are the side effects of lamivudine?

Its most common side effects are headache, fatigue, and nausea which generally subside over time. Other side effects include decreased appetite, diarrhoea, skin rash, and abdominal pain. Nausea and diarrhoea can be controlled with other medicines, which can be prescribed before starting lamivudine.

What is the indication for zidovudine?

Indications for: Zidovudine HIV-1 infection, in combination with other antiretroviral agents. Prevention of maternal-fetal HIV-1 transmission.

Does zidovudine have a black box warning?

Black Box Warning Zidovudine tablets have been associated with hematologic toxicity including neutropenia and severe anemia, particularly in patients with advanced HIV-1 disease.

What drugs should the client avoid while taking zidovudine AZT because they can cause bone marrow suppression?

Using AZT with these or other drugs that affect the bone marrow can increase the risk of infections and/or anemia:

  • dapsone (Avlosulfon)
  • ganciclovir (Cytovene)
  • ribavirin (used as treatment for hepatitis C)
  • valganciclovir (Valcyte)
  • valproic acid (Depakene, Divalproex, other brand names)

Which art drug should be avoided in pregnancy quizlet?

Cobicistat-boosted ARV drugs (ATV, DRV, or EVG) are Not Recommended for use in pregnancy. As noted above, EVG, DRV, ATV, and COBI levels have been found to be significantly lower during the third trimester than during the postpartum period.

Would you expect AZT and stavudine to be prescribed together?

AZT should never be combined with d4T (Zerit, stavudine), as these drugs interfere with each other. The following drugs can affect the bone marrow, decreasing the production of white and/or red blood cells.

What is the meaning of Haart?

Highly active antiretroviral therapy (HAART) is a treatment regimen typically comprised of a combination of three or more antiretroviral drugs. HAART may also be called antiretroviral therapy (ART) or combination antiretroviral therapy (cART).

Is zidovudine safe for patients with liver disease?

Zidovudine should be used with caution in patients with hepatic disease or in those with known risk factors for liver disease (e.g., alcoholism); however, cases of hepatotoxicity or lactic acidosis, including fatal cases, have been reported in patients with no risk factors.

Can you take zidovudine with ribavirin and interferon?

Ribavirin: (Moderate) Use zidovudine with ribavirin and interferon with caution and closely monitor for hepatic decompensation and anemia. Dose reduction or discontinuation of interferon, ribavirin, or both should be considered if worsening clinical toxicities are observed, including hepatic decompensation (e.g., Child-Pugh greater than 6).

Is it safe to take zidovudine and phenytoin together?

Phenytoin: (Minor) Coadministration with zidovudine has resulted in altered phenytoin concentrations. Reports have varied, with increased and decreased phenytoin concentrations being reported. Use combination with caution.

Can telbivudine and zidovudine be taken together?

Telbivudine: (Moderate) The risk of myopathy may be increased if zidovudine is coadministered with telbivudine. Monitor patients for any signs or symptoms of unexplained muscle pain, tenderness, or weakness, particularly during periods of upward dosage titration.