What does a positive anticardiolipin antibody mean?
A positive result means that cardiolipin antibody was detected in the blood. As mentioned earlier, the presence of cardiolipin antibodies may indicate several diseases, such as: Syphilis. Antiphospholipid syndrome (APS) Systemic lupus erythematosus (SLE)
What if VDRL test is negative?
A negative test is normal. It means that no antibodies to syphilis have been seen in your blood sample. The screening test is most likely to be positive in the secondary and latent stages of syphilis. This test may give a false-negative result during early- and late-stage syphilis.
How accurate is VDRL?
The VDRL test isn’t always accurate. For example, you may have false-negative results if you’ve had syphilis for less than three months, as it could take this long for your body to make antibodies. The test is also unreliable in late-stage syphilis.
What is anticardiolipin antibody?
Anticardiolipin Antibodies. The first anticardiolipin antibody (ACA) tests were developed in the early 1900s as a screening test for syphilis. 1 The Venereal Disease Research Laboratory (VDRL) test is a manual agglutination assay that detects antibodies to cardiolipin extracted from bovine heart tissue.
What is the VDRL test?
The basis of the VDRL test is that body produces antibody when infected, and in this test the antibody is detected by subjecting the serum to an antigen, which is composed of colorless alcoholic solution of beef cardiolipin, cholesterol, and lecithin.
What is the VDRL test for Treponema pallidum?
Like the RPR test, the VDRL test can be quantitated by examining serial dilutions of serum and can be used to follow the course of illness, including the response to therapy. Interpretation In a healthy person, the test is negative. This means that no antibodies to the organism that causes Treponema pallidum/bacteria.
What is the difference between anti-cardiolipin antibodies and lupus anticoagulant activity?
Anti-cardiolipin antibodies, the lupus anticoagulant test and the VDRL detect overlapping but not identical populations of antibodies. Anti-cardiolipin antibodies and lupus anticoagulant activity (haematology test) should be measured. The two assays do not always agree